Analysis of genes encoding outer membrane protein of leptospira interrogans and Its modulation due to host factors: an approach for understanding host-pathogen crosstalk

Abstract

The pathogens like Leptospira interrogans upon infection to human or animals and to sustain itself in the diverse host defense system have evolved sensor mechanisms to discern different host factors such as catecholamines (stress hormones), temperature, osmolarity, oxidative stress, etc. These pathogens exploit these host factors as an environmental cue to alter their growth and virulence for its survivability. The leptospiral outer membrane proteins are thought to be important for understanding.