Synthesis and characterization of Curcumin loaded poly 2 hydroxyethyl Methacrylate based nanoparticulate Drug delivery systems

Abstract

Nanoparticles are solid colloidal particles or particulate dispersions newlinewith particle size ranging from 10 1000 nm In recent years nanoparticle newlinetechnology has attracted attention as it improves the effectiveness of drugs newlinePolymeric nanoparticulate systems appear to be feasible and promising tool newlinefor delivery of many bioactive The development of polymeric nanoparticles newlinefor targeted delivery and controlled drug release may improve the therapeutic newlineindex of drugs as they are stable in blood non toxic non thrombogenic nonimmunogenic non inflammatory and biodegradable They also act as carriers newlinefor proteins peptides or nucleic acids newlineThere has been considerable interest in developing nanoparticles as newlineeffective drug carriers wherein the drug or biologically active material is newlineentrapped encapsulated adsorbed or attached Recently a nanoparticle newlineformulation of paclitaxel nanometer sized albumin bound paclitaxel newline Abraxane has been applied for the treatment of metastatic breast cancer newlineSynthetic polymers have contributed to further interest in this area Some of newlinethese polymers are known for their biocompatibility and resorbability through newlinenatural pathways Research is now focused on the preparation of newlinenanoparticles using hydrophilic polymers Their high degree of surface newlinehydrophilicity will enhance the circulation time of nanoparticles water newlinesolubility and decrease the sensitivity to enzymatic degradation newline newline