Genetic Physiological and Metabolic Biomarkers for predicting Cardiovascular Disease among Infertile Subjects

Abstract

ABSTRACT newlineInfertility is a serious health issue affecting millions of people of reproductive age worldwide. Various factors that may leads to infertility, some of them are lifestyle, genetic and even hormonal. Currently, cardiovascular disease (CVD) also becomes a leading case of mortality and its incidence rate is rapidly increasing. In some studies it was estimated that, by the year 2030 more than 22.2 million people will die annually from CVDs. Growing evidence suggests that increased CVD risk is associated with infertility caused by various physiological conditions such as PCOS, thyroid dysfunction, endometriosis etc. newlineInfertility is a multifactorial problem as similar to CVD. Therefore, a proper study for understanding the relation between CVD and infertility and also the role of DNA repair and damage should be carried out to limit the future risk of having CVD conditions. Present study consist of 180 clinically diagnosed infertile couples as test subjects and 140 age and sex matched healthy couples as control groups. Various biochemical parameters, lipid profile, oxidative profile, inflammatory profile and renal profile were evaluated and compared among study and control subjects. Moreover, DNA damage and repair efficiency was also analyzed. newlineFindings of current study point out that, individuals suffering from infertility showed an increased incidence of risk factors which leads to CVD. Increased oxidative stress, decreased DNA repair efficiency and increased DNA damages are observed in infertile patients. Even test subjects with abnormal karyotype also showed an increased mean CBMN frequency, MDA concentration and mean b/c value. Therefore, it is better to prevent the increase of oxidative stress and DNA damages which leads to CVD. Healthy lifestyle factors, including exercise and maintenance of balanced physiological conditions, are associated significant decreased of DNA damage. newline newline