Evaluation of Serum Iron Ferritin and C Reactive protein Levels in Patients with Head and Neck Carcinoma

Abstract

Evaluation of Serum Iron Ferritin and C Reactive protein Levels in Patients with Head and Neck Carcinoma newlineAbstract newlineIntroduction Cancer is a crucial health problem and one of the primary causes of death globally According to ICMR Cancer Statistics 2018 reported that Head and Neck Cancer are among the top 5 cancers in India Head and Neck cancer is a group of cancers that starts in the mouth nose throat larynx sinuses or salivary glands Lung cancer is the leading cancer site in males and major cause is smoking Iron is a component of hemoproteins and iron sulfur proteins Ferritin is part of the enzyme system which catalyses electron transfer and respiration reactions C reactive protein CRP is an acute phase protein and marker for inflammation newlineAim The present study was planned to assess the role of serum Iron Ferritin and C reactive protein Levels in Head and Neck Carcinoma patients Further the study aimed at evaluating the correlation of these markers among themselves Materials and Methods The total study population n300 was divided into two major groups Case group comprising of Cancer patients n150 and Control group comprising of age and sex matched healthy individuals n150 Histopathologically confirmed cases of Head and Neck age between 18 65 years were included and patients on Chemotherapy and Radiotherapy Post surgery cases and patients with any other chronic disease were excluded from the study Blood samples of selected participants were collected by veni puncture and used for the estimation of serum Iron Ferritin C reactive protein CEA Results Mean Serum Iron levels among cancer patients were significantly lower as compared to healthy controls Ferritin CRP and CEA levels were significantly higher in HNC Patients Mean Fe Ferritin and CEA levels were compared between Cancer patients on the basis of gender The average of all these three biomarkers in male patients was significantly higher than in female patients No significant difference was found between men and women in terms of serum Fe ferritin and CEA level