Design Development and Evaluation of Controlled Release Multiple Unit Pellets for Potential Delivery of Antiulcerants

Abstract

In the modern era of Pharmaceutical research much attention has been focussed on patient s health in terms of therapeutic efficacy and safety. Modified Dosage Form (MRDF) has always been more effective therapeutic alternative to conventional or immediate release. The term modified release drug product is used to describe product that alter the timing and /or the rate of release of the drug substances. There are two types of MRDF. (i) Delayed release, (ii) Extended release. The terms Controlled release (CR), Sustained release (SR) Prolong release (PR) has been used synonymously with extended release dosage forms. Controlled release drug delivery is one which delivers the drug at a predetermined rate for locally (or) systemically for a specified period of time. Controlled release drug delivery system aim to maintain plasma concentration of drugs within the therapeutic window for a longer period of time. Delayed release products are formulated with acid resistance (or) enteric coating protects acid labile drug substance from the gastric environment (or) to prevent adverse events such as irritation. From the above research finding it can be concluded that controlled release of Esomeprazole Magnesium and Rabeprazole Sodium Multiple Unit Pellets could be developed by using HPMC K100 the drug Polymer ratio 1:1.5 and HPMC K 15 the drug and polymer ratio 1:2 prepared by Extrusion-Spheronization to achieve better bioavailability and extended drug release. Further, the first group spheroid unit could maintain the minimum effective concentration and the second group spheroid unit could release the medicament in control release manner. Hence the prepared Multiple Unit Pellets could achieve both enteric coating and controlled release approach for the potential delivery of Antiulcerants. Compaction of multiple particulates, commonly called Multiple Unit Pellets (MUPS), is one of the more recent and challenging technologies that combine the advantages of both tablets and pellets filled capsules in one dosage forms.