Phytochemical characterization and neuroprotective assessment of standardized extract of pedalium murex linn leaves

Abstract

Neurodegenerative Ddiseases (ND) are threatening worldwide. Epidemiological studies obviously represent substantial burden on well-being. Previously countless medications are obtainable for ND, but all the drugs are symptomatic relief only and they do not ameliorate the total mechanism of illnesses. ND was traditionally treated with numerous herbal medicines because to minimize side and adverse effects, chemical pollution from synthetic medications. Publics are accepting the herbal medicines due to long history of usage, better patient tolerance, easy availability, cost effective, time consuming. Huge number of behavioural changes are associated with ND such as depression, anxiety, memory loss, stress and so on. It affects not only adult, even small kids also suffering a lot due to depression and stress. Effective drugs need to cure the ND from nature. Now a day, people are focused on an organic product from herbal plants. From the above results, we may conclude that EEPM may be a potential candidate for LPS-induced brain damage which may be attributed to the presence of potent antioxidants in EEPM. The results of this study warranted further research on active constituents of EEPM through molecular docking will lead new therapeutic approaches from nature. The present study emphasized a sum of researchable features that could be followed by phytochemical, in vitro antioxidant and free radical scavenging activities and neuroprotective effect assessed through a battery of behavioural and biochemical studies on Pedalium murex Linn leaves. Innovative level of phytochemical studies such as molecular docking analysis and analytical studies like x-ray crystallography, COSY, NMDR, 2D-NMR are recommended for isolation, identification and purification of various phytoconstituents present in the different solvent extracts of Pedalium murex Linn leaf. Advanced level of pharmacological studies through pharmacophore modelling are recommended to understand the clear mechanism of neuroprotective effect of Pedalium murex Linn leaf.