Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/414355
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dc.date.accessioned2022-10-25T05:48:54Z-
dc.date.available2022-10-25T05:48:54Z-
dc.identifier.urihttp://hdl.handle.net/10603/414355-
dc.description.abstractABSTRACT newlineChanges in lifestyle, such as high-calorie diet intake and lack of exercise, have increased the global prevalence of obesity and diabetes. The major pathophysiological event contributing to the development of type 2 diabetes mellitus is the target tissues to insulin action. Liver is the largest organ of the body that carries out all important metabolic processes of carbohydrate, protein, and lipid. It plays an important role in the regulation of glucose hemostasis. and#946;-sitosterol, a naturally occurring plant sterol, ubiquitously found in many plants. The study was aimed at assessing the effect of and#946;-sitosterol on insulin signaling molecules and glucose oxidation in the liver of high fat diet and sucrose induced type 2 diabetic adult male rats. Experimental Design: Adult male Wistar rats were used and divided as Group I: Control; Group II: Type-2 diabetic rats; Group III: Type-2 diabetic rats treated with and#946;-sitosterol and Group IV: Type-2 diabetic rats treated with metformin. After 30 days of treatment, animals were anesthetized; liver tissues were dissected out and used for the assessment of fasting blood glucose, oral glucose tolerance test, fasting serum insulin, insulin tolerance test, HOMA-IR, QUICKI, carbohydrate metabolic enzymes, antioxidant enzymes ,lipid profile, renal profile, liver enzymes, lipid peroxidation, glucose uptake , glucose oxidation, IRS protein and its mRNA expression, IRS 2 protein and its mRNA expression and GLUT2.CONCLUSION:The study highlighted, that the antidiabetic effect of and#946;-sitosterol in high fat diet and sucrose-induced type-2 diabetic rats were mediated through amelioration of oxidative stress and dyslipidemia, improved insulin signal transduction and GLUT2 expression as well as glucose uptake and oxidation in the liver. newline newline
dc.format.extentxviii 102
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleStudies on The Effect of Beta Sitosterol on Insulin Signaling Molecules and Glucose Oxidation in Liver of High Fat Diet and Sucrose Induced Type 2 Diabetic Adult Male Rats
dc.title.alternative
dc.creator.researcherSaravanan R
dc.subject.keywordBiochemistry and Molecular Biology
dc.subject.keywordBiology and Biochemistry
dc.subject.keywordLife Sciences
dc.description.noteBeta Sitosterol, High-fat Diet, Type-2 Diabetes
dc.contributor.guideAnandhi D
dc.publisher.placeChennai
dc.publisher.universityMeenakshi Academy of Higher Education and Research
dc.publisher.institutionDepartment of Biochemistry
dc.date.registered2017
dc.date.completed2022
dc.date.awarded2022
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Biochemistry

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01_title.pdfAttached File26.64 kBAdobe PDFView/Open
02_prelim pages.pdf3.57 MBAdobe PDFView/Open
03_content.pdf278.59 kBAdobe PDFView/Open
04_abstract.pdf82.04 kBAdobe PDFView/Open
05_chapter 1.pdf497.79 kBAdobe PDFView/Open
06_chapter 2.pdf359.59 kBAdobe PDFView/Open
07_chapter 3.pdf517.07 kBAdobe PDFView/Open
08_chapter 4.pdf1.8 MBAdobe PDFView/Open
09_chapter 5.pdf233.08 kBAdobe PDFView/Open
10_annexures.pdf702.29 kBAdobe PDFView/Open
11_chapter 6.pdf210.39 kBAdobe PDFView/Open
80_recommendation.pdf235.66 kBAdobe PDFView/Open


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