Antidiabetic Potential of Combinatorial Herbal Formulation in High Fat Diet Induced Type 2 Diabetic Rats A Molecular Approach

Abstract

ABSTRACT: newlineDiabetes mellitus is a non-infectious endocrine disorder which is characterized by the disturbance in metabolism of carbohydrate and associated with hyperglycemia. In India frequency of diabetes is progressively increases in urban area approximately 6 times more than compared to rural population. Female diabetic patients are more than compared to male diabetic patients because hormone and inflammation act differently in women. The utmost percentages of people having diabetes are lives in developing countries. Till date, medicinal research haven t succeed to identify the exact mechanism how patients developing diabetes and why it s not getting cured permanently. The present study is attempt to develop an herbal based antidiabetic drug, which will be evaluated by using in vivo method.The mixture of several crude extracts, when used in formulation, enhance the beneficial effects through synergistic amplification and diminishing any possible adverse effects and offer advantage over a single isolated ingredient. Hence, in the present study, Polyherbal formulation, a phytochemical combination constituting flowers of Cassia auriculata and leaves of Gymnema sylvestre seeds of Trigonella foenum graecum (Fenugreek), bark of Cinnamomum zeylanicum and seeds of Syzygium cuminiwas formulated in define ratio and evaluated for the first time with a view to potentiate more intense antidiabetic property. In the present study, it has been hypothesized that the synergistic action of components present in the Polyherbal formulation (PHF) might ameliorate the biochemical and signaling molecules in high fat diet induced type 2 diabetic rats. newline