Phytochemical constituents and therapeutic potential of ethanolic extracts of spine skin and rind of jackfruit artocarpus heterophyllus peel a comparative study

Abstract

The non edible jackfruit peel (JFP) constitutes one-third of the jackfruit and is thrown as a waste. The individual parts of jackfruit tree and the edible fruit portion have been reported to have many medicinal properties. However, JFP has not been evaluated for its therapeutic potential. As the fruit peels of pomegranate, orange, pineapple and others are found to have pharmacological activities the present study was undertaken to evaluate the phytochemical constituents of skin, spine and rind and the therapeutic potential of JFP. Methodology: JFP was separated into spine, skin and rind and subjected to extraction with seven different solvents. The ethanolic extract was taken for evaluation as the yield was maximum. The phytochemical constituents in ethanolic extracts were evaluated using appropriate chromatographic methods. The therapeutic potentials were tested for their antioxidant, anti coagulant, anti inflammatory and anticancer activities under in vivo and newlinein vitro experimental conditions. Results: The qualitative phytochemical screening of ethanolic extracts of JF spine, skin and rind was positive for flavonoids, glycosides, tannins, coumarins, sterols and terpenoids. The rind had the highest polyphenol and flavonoid content. The acute toxicity study revealed that the extracts were safe up to the dose of 2000 mg/kg in mice. The ethanolic extracts of the three parts exhibited different degrees of antiproliferative and anti-inflammatory effects in vitro. The rind extract was found to have better anti-inflammatory and skin antioxidant activity. The spine extract had significant anti-tumor effect than skin and rind in vitro and in vivo. The extract did not exhibit anti coagulant activity.Conclusion: The ethanolic extracts of spine, skin and rind of JFP were found to contain polyphenols and flavonoids and they have different degrees of anti-inflammatory, antiproliferative and antioxidant activities exhibiting their therapeutic potentials. newline newline