MICROWAVE ASSISTED SYNTHESIS OF 3 NITRO 2 PHENYL 2H CHROMENE AND 6H CHROMENO 4 3 4 5 IMIDAZO 1 2 a PYRIDINE

Abstract

Growing alertness towards the implications of antibiotic resistance for public health among newlineresearchers as well as clinicians has urged the need to think of ways to fight the infections of newlinemicroorganisms. According to the World Health Organization (WHO), antibiotic resistance is newlinea mounting risk to public health. Among several types of bacterial infections, urinary tract newlineinfections (UTIs) are the second-most emerging bacterial infection found in both community newlineand hospital settings. Millions and millions of people were affected by UTI each year because newlineof uropathogenic Escherichia coli bacterial strains. Indeed, over 90% of uncomplicated UTIs newlineare caused due to the Gram-negative bacterium E. coli and complicated UTIs are caused by newlineEnterococcus sp., Klebsiella pneumoniae, Proteus. mirabilis, Pseudomonas aeruginosa, and newlinefungi, Candida sp., including several Gram-positive bacilli. Patients who are affected with newlineUTIs, are treated with drug-resistant strains due to the administration of antibiotics. The newlinewidespread use and mistreatment of antibiotics are increasing a variety of multidrug-resistant newlinestrains resulting in a big threat to human health. Hence, in recent times, the launching of new newlineantibiotics with the exact mode of action is highly desirable as the golden era of antibiotics is newlinefading away progressively. A spectacular approach was taken to widen the area of research in newlinemedicinal chemistry and modify the previously used antibacterials to form a promising lead newlinemolecule. In this method, new pharmacophoric groups were introduced in the mainstream newlinewhich provides an enhanced biological activity to combat the infections of microbial newlinepathogens. newline