Comparison of Microwave Assisted and Conventional Degradation of Drugs

Abstract

The drug development life cycle is a time-consuming process, which also involves lots of effort in the testing of the chemical stability of the drug molecules and possible impurity and degradation product of the drug before it comes in the form of a stable formulation. The Forced degradation and stability testing involve the major time portion in researching the chemistry of the molecules. To get a green and rapid method for forced degradation study of the drug molecules, the selected drug molecules were degraded using a microwave-assisted forced degradation process. Microwave-assisted degradation, being a different mechanism, is compared with the forced degradation process in conventional mode. newlineDrugs from the cardio diabetic category Sitagliptin, Linagliptin, Nifedipine, Cilnidipine, Canagliflozin, Telmisartan, and Rosuvastatin were selected. The hydrolytic degradation of drugs was performed in acid, alkaline, and neutral media. The preliminary degradation was performed at microwave power level 400 Watts for 2 min and 80 ° C for 2 hours. The results of the degradation were compared using validated chromatographic methods. The number of peaks and pattern of degradation were observed. After having data from the preliminary degradation study suitable degradation conditions were selected for the kinetics study. It was performed for each drug to get insight into the rate of degradation. The microwave-assisted degradation appears to be eight to ten times faster than conventional degradation. The microwave-assisted degradation gives the same results as that of conventional so it can be further used for stability-indicating method development and impurity analysis for drug substances. newline newline newline