Binding interaction of some indole based receptors with ions and molecules spectroscopic and computational studies

Abstract

In chapter I, we have discussed and reviewed on binding interaction and sensing behavior of different receptor molecules with environmentally important ions ad molecules. Here, we discussed the major techniques (both experimental and computational) usually employed in studying binding interaction newlineand sensing phenomena of different probe molecules. Then, different photochemical processes {(hydrogen bonding, proton transfer, intramolecular charge transfer (ICT), twisted intramolecular newlinecharge Ttransfer (TICT), photoinduced electron transfer (PET)} generally involved in sensing of newlinedifferent anions (fluoride, bisulfate, acetate, dihydrogen phosphate and cyanide) and small molecules newline(picric acid, water and amino acids) were reviewed with example of some recent reports. The whole newlineliterature survey revealed that most of the reported ion and molecule sensors were synthetic. These newlineinsisted us to survey on commercially available molecules. Then, we realised that quotoff-the-shelfquot newlineindole based molecules (carbazole, norharmane, harmane, harmine, ellipticine, isoellipticine etc.) newlinemight have good binding behavior toward anions and small molecules. Thereafter, we explored the sensing behavior of indole based molecules towards anions and small molecules that are well discussed subsequently.Then in chapter II, we discussed the development of different computational methods with Gaussian newlinein solving properties of molecules computationally. In the subsequent section, we mentioned the newlinesources of different reagents and solvents used in our research work. Later, we mentioned the sources newlineand features of different instruments employed during our whole research work. At the end of this chapter, block diagrams of spectrophotometer and fluorimeter were presented.In my first work, the anion selective binding behavior of ellipticine (Scheme 2) was explored by newlineemploying computational methodology. newline