Diclofenac Sodium Loaded Gelatin Microspheres for Controlled and Targeted Drug Delivery Preparation Characterization and in Vivo Studies in Rabbits

Abstract

For centuries various ailments have been treated by means of administering drugs of different kinds Galanicals and powders were initial dosage forms to deliver the drugs Presently drugs are being delivered as tablets pills capsules creams liquid orals and injections Eventhough these conventional drug delivery systems guarantee a prompt release of drug they fail to maintain drug concentration within the therapeutically effective range for the required period To maintain effective plasma concentration of the drug these dosage forms must be administered frequently Bruck 1983 Mordenti and Williams 1988 This causes significant fluctuation in the drug plasma concentration and results in ineffective therapy Moreover these conventional delivery systems deliver the drug not only to its site of action but also to other parts of the body leads to adverse drug reactions Another serious problem of these conventional dosage forms is that instead of delivering minimum effective concentration of drug at the site or organ it often produces higher concentration which also resulting in untoward adverse reactions newline The newer forms of drug delivery systems have emerged largely to overcome the problems experienced with the conventional dosage forms An ideal drug delivery system in addition being therapeutically effective and non toxic should achieve and maintain effective therapeutic plasma concentration for an extended period This can be solely achieved by the use of modern and sophisticated techniques universally known as NOVEL DRUG DELIVERY SYSTEMS Chein 1992 The goals in designing novel drug delivery systems are spatial placement and temporal delivery of drug Spatial placement relates to targeting drug to its site of action while temporal delivery refers to controlling the rate of drug delivery to the target tissue Chiao and Robinson 1995 newline