Thermo mechanical assesment of nanoparticle mixed vascular tissues subjected to laser and ultrasound heating

Abstract

Hyperthermia is an effective non-conventional therapeutic technique to cure cancer. Concerning a target specific tumor ablation preserving the healthy tissues, advancements in laser, ultrasound and nanotechnology plays an important role in the field of non-invasive cancer treatment. In addition, proper assessment of induced thermal pain during the ablation process in terms of the thermoelastic responses of tissue is a useful step prior to real clinical practice. newlineIn the first part of study, the therapeutic effect of injecting gold nanoshells intravenously and intratumorally under NIR laser irradiation is predicted on a single layered vascular skin -tumor model. The respective thermal and damage history of tissue is solved in a 3-D model including the inhomogeneous tissue behavior in terms of thermally significant large blood vessels and time lagging characteristics of tissues. In the second part of study an in-vitro experiment on agar based vascular tissue phantom is performed to measure the therapeutic effect of loading gold nanorods intravenously and intratumorally under NIR laser irradiation. In the third part of study the therapeutic effect of intravenous and intratumoral loading schemes of gold nanoshells is analyzed numerically in a complex multi layered skin tumor structure embedding multi-level branched counter current blood vessels under the NIR laser irradiation. In the last part of study the thermal and viscoelastic response of deeply seated tumor under laser and ultrasound based therapy is studied numerically. The primary target is to understand the therapeutic effect of pulse and continuous mode heating schemes during the nanoparticle assisted high intensity focused ultrasound and laser interstitial thermal therapy. A complex 3-D conceptual breast tumor model is developed concerning the inhomogeneous tissue situations.