Serum Surfactant Protein D levels in Chronic Obstructive Pulmonary Disease Association with Lung functions grades of severity and atherogenic risk

Abstract

newline Serum surfactant protein D levels in chronic obstructive pulmonary disease: newlineassociation with lung functions, grades of severity and atherogenic risk newlineABSTRACT newlineBackground: Global Initiative of Chronic Obstructive Lung Disease defines COPD newlineas a preventable and treatable disease. Increasing prevalence of COPD worldwide, newlineidentifying COPD as one of the major cause of morbidity and mortality globally. It newlineappears that misdiagnosis of COPD, lack of uniformity in diagnosis and newlineunderutilization of spirometry are responsible for under diagnosis of COPD from newlineepidemiological studies. There is a need to focus on the newer diagnostic strategies newlinefor early diagnosis and timely intervention to prevent progression of the disease and newlineassociated cardiovascular morbidity. Previous research workers who investigated the newlinerole of different biomarkers such as CRP, IL-6, fibrinogen and Surfactant Protein D newline(SP-D) suggested SP-D as a promising biomarker to access the severity of COPD newlineand its therapeutic utility. Material and methods: This study enrolled 108 COPD newlinepatients and 30 age and gender matched healthy control subjects. Based on GOLD newlinecriteria COPD patients were classified in to (32 Mild, 40 Moderate and 36 Severe). newlinePulmonary functions test were performed by spirometery in all the study population. newlineEstimation of SP-D and lipid profile was done by standard methods in use. newlineAtherogenic risk of COPD patients was investigated by calculating atherogenic newlineindex. Results: The observation revealed significant decline in ventilatory functions newlinewith increasing severity of COPD as reflected by decrease in FEV1% and newlineFEV1/FVC ratio as compared to controls (p= lt0.001.) Serum SP-D levels were newlinesignificantly increased in COPD patients ( Mild - 147.41 ± 25.71, Moderate 191.42 newline± 19.97 and Severe 326.75±32.19 ng/dl ) as compared to control group(58.53± 8.74 newlineng/dl) (p= lt0.001). A negative correlation was established between SP- D levels and newlinespirometric indices of COPD group (Mild - r = -0.603, p = lt0.001, Moderate r =- newline0.5