Design synthesis and chemistry of flexible models based on pyrazolo 3 4 d pyrimidines and related compoundes for understanding aromatic stacking interactions

Abstract

In the present work embodied in this thesis various factors affecting the intramolecular arene interactions in pyrazolo 3 4 d pyrimidine core based flexible models have been investigated to help in understanding the role of different factors on these interactions newlineChapter I deals with the effect of orientation on intramolecular interactions by linking two pyrazolo 3 4 d pyrimidine units with different linkers through different positions newlineChapter II involves the study of the effect of different substituents on the folded compounds due to intramolecular interactions ie the effect of increasing and decreasing the electron density in the aromatic system on arene interactions newlineIn Chapter III pyrazolo 3 4 d pyrimidine system has been linked to other related heterocycles to study the generality of pyrazolo 3 4 d pyrimidines as a tool for studying arene interactions newlineThe Chapter IV involves the addition of further pyrazoIo 3 4 d pyrimidine units on the already folded systems to study the newlinecooperative effect on arene interactions The analysis of the results was made by H NMR studies and supported by X ray crystallographic studies