Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/398395
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dc.date.accessioned2022-08-12T12:44:48Z-
dc.date.available2022-08-12T12:44:48Z-
dc.identifier.urihttp://hdl.handle.net/10603/398395-
dc.description.abstractnewline Endemic fluoride ingestion through drinking water leads to detrimental health newlineeffects in human communities. Boosted fluoride concentration in the blood, traverse newlinethe blood-brain barrier; induces free radical over production in lens that triggers lens newlineprotein denaturation, aggregation and precipitation leading to lens opacification newline(cataract). Free radicals having the potentiality to disconcert the eye lens homeostasis, newlineleading to loss of lens transparency. Free radicals oxidize the eye lens protein (protein newlinecarbonylation). The proportion of protein carbonylation gradually increased with the newlineincreased concentration of fluoride. Lenses are composed of transparent crystalline newlineprotein; and the oxidation of lens proteins by free radicals or reactive oxygen species newlineinducing to lens opacification, resulting in cataractogenesis. Fluoride significantly newlineincreases the opacification in the eye lenses with the increasing fluoride newlineconcentration. Fluoride induced cataractogenesis include the main mechanism of newlinebiochemical alterations in the in the aqueous humor along with decrease in the newlineactivity of antioxidant enzymes such as Superoxide dismutase (SOD), Catalase (CAT) newlineand Glutathione (GSH) due to reactive oxygen species causing excessive oxidative newlineburden in eye lens. Catalase is being a one of the important enzyme of innate newlineenzymatic defense system of the lens; is responsible for the detoxification of newlinehydrogen peroxide (H2O2). Oxidative stress biomarkers such as lipid peroxidation newline(Malondialdehyde) and protein carbonylation (PC) are employed for oxidative newlinedamage of lens. Endogenous antioxidant such as reduced glutathione is present in newlinesignificant concentration in lens; Superoxide dismutase and catalase maintain the free newlineradicals level below toxicity standards. Decreased activities of these antioxidant newlineenzymes in eye lens results significantly increased the toxic effect of highly reactive newlinefree radicals; leading to the loss of integrity and function of eye lens. Glutathione is a newlinemajor antio
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dc.languageHindi
dc.relation
dc.rightsuniversity
dc.titleInvitro Study on the effect of fluoride on Goat eye lens proactive potential of herbal preparation
dc.title.alternative
dc.creator.researcherRathore,Sumer Singh
dc.subject.keywordBiology
dc.subject.keywordBiology and Biochemistry
dc.subject.keywordLife Sciences
dc.description.note
dc.contributor.guideChauhan, Dushyant singh and Triphati, Sandeep
dc.publisher.placeJaipur
dc.publisher.universityNims University Rajasthan
dc.publisher.institutionDepartment of Biotechnology
dc.date.registered
dc.date.completed2021
dc.date.awarded
dc.format.dimensions
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Biotechnology

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12_chapter-2.pdf643.12 kBAdobe PDFView/Open
13_chapter-3.pdf147.2 kBAdobe PDFView/Open
14_chapter-4.pdf223.94 kBAdobe PDFView/Open
15_chapter-5.pdf194.5 kBAdobe PDFView/Open
16_chapter-6.pdf84.35 kBAdobe PDFView/Open
17_bibliography.pdf124.48 kBAdobe PDFView/Open
1_title page.pdf289.07 kBAdobe PDFView/Open
3_abstract.pdf24.31 kBAdobe PDFView/Open
4_acknowledgements.pdf45.67 kBAdobe PDFView/Open
5_undertaking (research scholar).pdf64.81 kBAdobe PDFView/Open
6_certificates.pdf151.4 kBAdobe PDFView/Open
7_contents.pdf44.52 kBAdobe PDFView/Open
80_recommendation.pdf2.56 MBAdobe PDFView/Open
9_list of tables.pdf34.88 kBAdobe PDFView/Open


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