Metal Free Synthesis of Aromatic Heterocycles and Biological Evaluation of Heterocyclic Hybrid Molecules

Abstract

In the present study, we have demonstrated for the first time a simple and environmentally friendly strategy towards production of and#946;-carbolines using a domino Pictet-Spengler reaction and aromatization in O2 atm in NMP. The reaction takes place in a metal-free solvent-promoted system at 140 °C in an oxygen atmosphere, and it works without the need of any base or additives. The reaction was found to be appropriate for the production of and#946;-carboline esters, and#946;-carbolines. Furthermore, the same reaction was carried out in an Ar atm with a catalytic amount of 4-nitrobenzoic acid in NMP produced THand#946;C s. Additionally, the scope of the reaction methodology was also extended for the total production of and#946;-carboline based natural products with biological importance newline