Anisotropy analysis on trabecular Architecture in radiographic femur Bone images using spectral and Multiscale spatial methods

Abstract

Estimation of mechanical strength of bones is an essential newlinecomponent in assessment of onset and progress of osteoporosis and fracture newlineAnalyses of bone mineral density and soft bone architecture of femur are newlineconsidered clinically important in explaining the mechanical variability of newlinebone and in determining fracture risk and bone disorders Trabecular bone is a newlinehighly complex anisotropic material that exhibits varying magnitudes of newlinestrength in compression and tension Trabecular microstructure is typically newlineoriented such that it is organized along the lines of the mechanical forces newlineapplied to bone This microstructural directionality contributes to trabecular newlinebone anisotropy Alteration of trabecular architecture due to pathology newlinemanifest as loss of trabecular plates and connection and results in alterations newlineof structural anisotropy An understanding of anisotropy of bone is important newlinefor diagnosis of osteoporosis like bone disorders newlineIn this work anisotropy of compressive and tensile strength regions newlineof femur trabecular bone is analyzed using spectral and multiscale spatial newlinemethods The normal and abnormal femur trabecular bone radiographic newlineimages are considered for this study The sub anatomic regions which newlineinclude compressive and tensile regions are delineated using pre processing newlineprocedures The apparent porosity which is a key representative of trabecular newlinearchitecture is derived as a ratio of void area to total area of delineated newlinestrength regions The anisotropy of trabecular architecture is investigated newlineusing various image processing techniques such as spectral and multiscale newlinespatial methods newline newline