Randomized controlled clinical study to evaluate the efficacy of mehamudgara rasa in the management of madhumehjanya nadiprathan shotha wrt diabetic neuropathy

Abstract

Diabetic Neuropathy is a nerve damaging disorder associated with Diabetes Mellitus. Prevalence of diabetic neuropathy in India Diabetic micro-vascular injuries involving small blood vessels that supplies to nerves i.e.vasa nervorum are responsible for diabetic peripheral Neuropathy. is about 26.1%.Aim and Objectives: -To evaluate clinical Efficacy of Meha-Mudgara Rasa in the management of Madhumehajanya Nadipratan Shotha w.r.t Diabetes Neuropathy.Methodology: In Group A 58 patients and in Group B 62 patients suffering from diabetic sensory polyneuropathy fulfilling the inclusion criteria were enrolled randomly in two groups. Out of these in Group A, 8 patients were dropout and In Group B, 12 patients were dropout.Group A (Meha Mudagara Rasa) and Group B (Pregabalin 75 mg) for the duration of 1 month. Conclusion: Both the drugs are effective on subjective parameters with wilcoxon test.On comparing the effect on subjective parameters with Mann-Whitney the statistical difference is seen MMR VS Pregabalin.With effect on objective parameters in Group A, with paired t test there is statistical difference in MMR is seen in HB, BSL-PP,VPT-RT andLT Foot.With effect on objective parameters in Group B, with paired t test ,there is statistical difference is seen in VPT RT andLT Foot.On comparing the effect on objective parameters with unpaired t test no statistical difference is seen MMR VS Pregabalin. Both the drugs found to be safe s no adverse effects were observed.