Synthesis and Biological Evaluation of Nitrogen and Sulphur Containing Heterocyclic Compounds

Abstract

newlineThe thesis is aimed at the design of novel nitrogen and sulphur-containing heterocyclic compounds by various principles of synthetic organic chemistry. The thesis comprises of the sections like introduction, review of literature, description of the materials used, and experimental methods employed, results and discussion and finally summary, conclusions and future prospects of the research work. newlineAs a part of our research efforts in developing new heterocycles containing both nitrogen and sulfur moieties, and after screening their microbial studies. In the present investigation, a first novel series of compounds 4-oxo-thiazolidine containing pyridine derivatives (6a-j) were synthesized by Multiand#8208;component reactions (MCRs). An efficient multiand#8208;component reaction approach is used for the synthesis of series of N-methyl-4-[4-(4-oxo-2-aryl-1,3-thiazolidin-3-yl)phenoxy]-pyridine-2-carboxamide derivatives. The newly synthesized molecules are characterized by elemental analysis, FT-IR, 1H-NMR, 13C-NMR, Mass spectroscopy etc. and studied for their antimicrobial and antioxidant activities. In addition, docking studies were also performed to get greater insight into the shown activity of these molecules. The present chapter deals with newly synthesized thiazolidine compounds (6a-j) were screened for their antimicrobial activity against different strains of bacteria and fungi using pour plate method. An antioxidant activity of compounds (6a-j) was carried out by DPPH and NO scavenging method. Few compounds have shown a significant microbial and antioxidant activity against selected bacterial strains (IC50). Molecular modeling studies of N-methyl-4-[4-(4-oxo-1,3-thiazolidin-3-yl)phenoxy]pyridine-2-carboxamide series derivatives 6a, 6f and 6g are the most active among all synthesized analogs. Another novel series of fluorine containing quinolone amide derivatives (4a j) were synthesized. The structures of synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectroscopy. The present paper deals with