Pharmacological Evaluation and Cardioprotective Role Of Partharishtam

Abstract

Context: Herbs have been used as medicines since decades and some derivatives (eg, reserpine, aspirin, and digitalis) have become mainstays of human pharmacotherapy. For CVD, herbal treatments have been used in individuals suffering with systolic hypertension, congestive heart failure, angina pectoris, cerebral insufficiency, atherosclerosis, venous insufficiency, and arrhythmia. But, many medicinal herbs used today have not undergone careful scientific valuation, and some have the ability to cause serious toxic effects and major drug-to-drug interactions. newlineAim: This study was carried out to analyze the cardioprotective efficacy of Patharishtam (an ayurvedic formulation) for the treatmet of myocardial infarction in rat model. The therapeutic efficacy of Partharishtam was compared with standard drug, Propranolol. newlineMethods: GC- MS analysis was carried out to find various bio active molecules present in this ayurvedic formulation, Partharishtam, which is a known cardio tonic medicine. The invitro antioxidant effect of the formulation was assessed depending on the scavenging effect on the stable DPPH, ABTS, hydroxyl, hydrogen peroxide and ferric free radical activity. The acute and toxicity study on the effect of Partharishtam on rat model was carried out to determine the drug safety upon administration. Then the cardioprotective property of Partharishtam was proved by analysing the cardiac biomarkers, cardiac tissue marker enzymes, antioxidants and histology architecture in isoproterenol induced myocardial infarction rats.Results and Conclusion: From GC-MS analysis data we analysed the various bio active molecules present in this Partharishtam, which is a known cardio tonic medicine. The percentage (%) of free radical inhibition was high with increasing the concentration of Partharishtam and as compared with standard. The medicinal properties of the molecules in Partharishtam and its antioxidant properties possibly will substantiate well with the claim that Partharishtam is a potent cardio tonic formulation.