Mancozeb and Monocrotophos Based Pesticide Alters the Behavior Response Associated with Oxidative Stress and Transcription of Genes Related to Apoptosis in Adult Zebrafish Danio Rerio Brain

Abstract

Pesticide usage has seen a significant increase in India because of the green newlinerevolution. Government agencies that monitor agricultural chemical usage have failed to newlinereach out to monitor usage by farmers. Therefore, most farmers are not aware of the newlinesevere effects of these toxic chemical pesticides and use pesticides newlinecarelessly. Monocrotophos (MCP) and Mancozeb (MZ) are highly hazardous pesticides newlinethat belong to the organophosphate and carbamate group used extensively in agriculture newlineand animal husbandry. Toxicity due to MCP and MZ exposure could occur in both newlineoccupational and non-occupational settings. Exposure to pesticides induces oxidative newlinestress, which changes various aspects of the central nervous system, including memory, newlinecoordination, and continuous attention. The main culprits in neuropsychiatric and newlineneurodegenerative illnesses, such as major depressive disorders, are oxidative stress and newlinefree radical generation. Zebrafish (Danio rerio) is a tropical freshwater fish belonging to newlinethe family Cyprinidae. Fish may be used as model organisms to predict mechanisms and newlineimpact of toxic substances on other fish species. Hence, the present study aims to newlineunderstand these alterations in behaviour, oxidative stress parameters, and intracellular newlinemarkers for apoptosis and their correlation with a mental disorder that might facilitate newlineearly diagnosis and better therapy for pesticide poisoning newline