Anti Ulcer Potential of Standardized Extract of Paederia foetida Linn: a traditional medicinal plant used by the tribals of northeast India

Abstract

Development of management therapy for peptic ulcer disease PUD is one of the thrust area of research to the scientist It is becoming the most important therapeutic areas to study due to its high mortality and morbidity India rank 5th with a death rate of 1237 lakh population where as in United States the direct or indirect treatment cost of PUD was estimated more than USD 34 billion annually As PUD is a multifactorial disease so there are several issues that need to be solved The major issues remain to resolved immediately are the optimal way to eradicate H pylori, solution of antibiotic resistance development, prevent ulcer recurrence in NSAIDs patients, minimizing the concomitant use of medicine etc Due to the existing side effect or limitations of currently available first line treatment of PUD, Food and drug administration release safety alert regarding the long term use of the PPIs omeprazole, lansoprazole, pantoprazole etc and H2 blocker ranitidine, famotidine To resolve such crucial problem we focused our study to nature substances According to WHO 80 percent of people rely on traditional medicine for their primary health care Focusing on this we have done ethnobotanical field survey among the tribal community of Tripura to explore the richness of traditional claim newlinePaederia foetida L is a popular edible plant of tribes of Northeast India Upon analyzing the survey outcome, P foetida considered as a one of the potent plant having therapeutical interest related to PUD The plant material leaf was collected from the tribal dominated market of Agartala, Tripura Authentication of the plant was done from NISCAIR, New Delhi Soxhlet methanolic extraction was yielded 3621 percent w w of extractive value newline