Antidyslipidemic Activity of Extracts of Gloriosa superba Valeriana wallichii Odenlandia corymbosa in Rats

Abstract

Dyslipidemia is a common public health problem. The term dyslipidemia means newlineabnormal lipid levels in plasma. This can be consequent to excess production, defective newlinetransport, delayed peripheral clearance, reduced utilization of lipoproteins or their newlineintermediates or a combination of these abnormalities. The causes responsible for such newlinelipid disorders could be primary or secondary to diabetes mellitus, nephrotic syndrome, newlinehypothyroidism etc.Dyslipidemia generally manifests as elevation of total cholesterol newline(TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) concentrations, newlineand a decrease in the high-density lipoprotein cholesterol (HDL-C) concentration in newlineplasma.Overall, dyslipidemia is defined by TC, LDL-C, TG, apolipoprotein B and newlinelipoprotein (a) levels in the upper 90th percentile or HDL-C and apolipoprotein A1 levels newlinebelow the 10th percentile of general population.Dyslipidemia covers a broad spectrum of newlinelipid abnormalities, but TC,LDL-C and HDL-C have received the maximum attention. newlineIt is well documented that abnormalities in lipid metabolism contribute significantly to newlineinitiation and progression of cardiovascular disease (CVD). In particular, elevation of TC newlineand LDL-C levels, and decrease in HDL-C levels are known to predispose to CVD. CVD newlineis the single largest cause of death in the developed countries and is among the leading newlinecauses of death and disability in the developing nations as well. South Asians around the newlineglobe have the highest rates of Coronary Artery Disease (CAD).National Commission on newlineMacroeconomics and Health (NCMH), a Government of India undertaking, had predicted newlinethat there would be around 62 million patients with CAD by 2015 in India and of these, newline23 million would be patients younger than 40 years of age.Dyslipidemia has been found newlineto be one of the most important contributing factors. It has long been known that lipid newlineabnormalities are major risk factors for premature CAD. newlineThere has been a rapid increase in the prevalence of dyslipidemia. Dyslipidemia is an newlineindependent r