Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/368585
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dc.date.accessioned2022-03-16T09:07:55Z-
dc.date.available2022-03-16T09:07:55Z-
dc.identifier.urihttp://hdl.handle.net/10603/368585-
dc.description.abstractThe aim of the present study is to know the effectiveness of newlinevancomycin among methicillin sensitive S. aureus (MSSA), establish reliable newlinemethod to determine the vancomycin susceptible S. aureus (VSSA), newlinevancomycin intermediate resistant S. aureus (VISA), vancomycin resistant S. newlineaureus (VRSA), evaluation of its drug resistance and useful antibiotics for its newlineinfections in rural tertiary care centre (R-TCC) and urban tertiary care centre newline(U-TCC). It is concluded that S. aureus causing pyogenic infection has no newlineassociation with age and gender. VanA gene loci is plasmid mediated and newlinehorizontal gene transfer from one bacterium to other in gram positive bacteria newlineand which is not related to methicillin sensitive or resistance. For detection of newlineVRSA strains any one method can be used out of three method i.e. agar newlinedilution (AD), E-test (ET) and PCR (vanA gene) methods but disc diffusion newline(DD) method is not found reliable in both centres. In case of VISA strains, newlinePCR is the only and best method for detection in both centres. Antimicrobial newlineresistance in VRSA strains showed high resistance, VISA strains showed newline- 110 - newlinemoderate resistance and VSSA showed least drug resistance in both centres newlinerespectively, R-TCC showed more drug resistance as compared with U-TCC. newlineIt indicates that rural population suffers from the emergence of superbug newlinebacterial infections. This can be controlled by good infection control, newlineconservative infection measures, prudent use of antibiotics, and good newlinehygiene. Finally, the present study reveals if vancomycin is stopped for about newlinefor a certain period, the vancomycin resistance gene (VanA) in plasmid will be newlinereverted in future. Otherwise drug resistance may occur shown in the present newlinestudy. It will be a boon in future, providing an important antibiotic for critical newlinecare conditions newline
dc.format.extent
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleEffectiveness of vancomycin among methicillin sensitive Staphylococcus aureus in rural and urban tertiary care centres
dc.title.alternative
dc.creator.researcherSrinivasa Budati
dc.subject.keywordLife Sciences
dc.subject.keywordMicrobiology
dc.description.note
dc.contributor.guideBandaru Narasinga Rao
dc.publisher.placeChennai
dc.publisher.universitySaveetha University
dc.publisher.institutionDepartment of Microbiology
dc.date.registered2015
dc.date.completed2020
dc.date.awarded2020
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Microbiology

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01_title.pdfAttached File14.94 MBAdobe PDFView/Open
02_certificate.pdf14.94 MBAdobe PDFView/Open
03_abstract.pdf14.94 MBAdobe PDFView/Open
04_declaration.pdf14.94 MBAdobe PDFView/Open
05_contents.pdf14.94 MBAdobe PDFView/Open
06_list_of_tables.pdf14.94 MBAdobe PDFView/Open
07_list_of_figures.pdf14.94 MBAdobe PDFView/Open
08_abbreviations.pdf14.94 MBAdobe PDFView/Open
09_chapter1.pdf14.94 MBAdobe PDFView/Open
10_chapter2.pdf14.94 MBAdobe PDFView/Open
11_chapter3.pdf14.94 MBAdobe PDFView/Open
12_chapter4.pdf14.94 MBAdobe PDFView/Open
13_chapter5.pdf14.94 MBAdobe PDFView/Open
14_chapter5.pdf14.94 MBAdobe PDFView/Open
15_conclusion and summary.pdf14.94 MBAdobe PDFView/Open
16_bibliography.pdf14.95 MBAdobe PDFView/Open
80_recommendation.pdf14.94 MBAdobe PDFView/Open


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