Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/368578
Title: | The Effectiveness of Preemptive Analgesia With Pregabalin in Surgical Management Of Maxillofacial Trauma A Randomized Controlled Trial |
Researcher: | Subashini |
Guide(s): | Abdul Wahab |
Keywords: | Clinical Medicine Clinical Pre Clinical and Health Dentistry Oral Surgery and Medicine |
University: | Saveetha University |
Completed Date: | 2021 |
Abstract: | Maxillofacial trauma occurs in a significant proportion worldwide. It can occur as newlinean isolated injury or in combination with other injuries like Cranial, Spinal, newlineExtremities and Abdomen.The mandible is the most common facial bone to get newlinefractured because of its prominent and exposed position. Most common newlinetreatment modality for maxillofacial fractures is Open reduction and internal newlinefixation (ORIF) and it has been associated with trauma to the tissues and thereby newlineinflammation. The inflammatory process releases histamines, serotonin, newlinebradykinin etc produces pain. It has been shown in experimental studies that newlineanalgesic administration preceding surgical injury can reduce post traumatic newlinesensitivity and secondary hyperalgesia. newlineAim newlineTo evaluate the efficacy of preemptive analgesia with Pregabalin on newlinepostoperative pain after open reduction and internal fixation (ORIF) for newlinemaxillofacial trauma. newlineMaterials and Methods newlineWe conducted a prospective, randomised, controlled, double blinded study of newline32 patients who required ORIF for maxillofacial trauma under general newlineanesthesia. Patients were divided into two groups, a Study group (n=16) who newlinereceived 150mg of Cap. Pregabalin peroral one hour before the induction and a newlinecontrol group (n=16) who did not receive any drug. Pain was assessed using newline15 of 105 newlineVisual Analogue Scale (VAS) at different time intervals like Preop, 1,6,12,24 newlinehours after surgery and the number of analgesics used in the first 24 hours. newlineResults newlineStatistical analysis of the data indicated the mean pain score at 1,6,12 and 24 newlinehours postoperatively was significantly decreased in the Pregabalin group newline(p=0.01) and It was observed that the study group consumed less analgesic newlinewithin 24 hours as compared to the control group which was statistically newlinesignificant (P = 0.001). newlineConclusion newlineThe results of our study suggest that preemptive analgesia with pregabalin for newlineopen reduction and internal fixation after maxillofacial trauma is effective in newlinereducing post operative pain. newline newline |
Pagination: | |
URI: | http://hdl.handle.net/10603/368578 |
Appears in Departments: | Oral and Maxillofacial surgery |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf.pdf | Attached File | 160.52 kB | Adobe PDF | View/Open |
02_certificate.pdf.pdf | 168.16 kB | Adobe PDF | View/Open | |
03_abstract.pdf.pdf | 153.18 kB | Adobe PDF | View/Open | |
04_declaration.pdf.pdf | 172.61 kB | Adobe PDF | View/Open | |
05_acknowledgement.pdf.pdf | 153.57 kB | Adobe PDF | View/Open | |
06_contents.pdf.pdf | 920.28 kB | Adobe PDF | View/Open | |
07_list_of_tables.pdf.pdf | 149.15 kB | Adobe PDF | View/Open | |
08_list_of_figures.pdf.pdf | 149.56 kB | Adobe PDF | View/Open | |
09_chapter 1.pdf.pdf | 202.83 kB | Adobe PDF | View/Open | |
10_chapter 2.pdf.pdf | 204.61 kB | Adobe PDF | View/Open | |
11_chapter 3.pdf.pdf | 148.09 kB | Adobe PDF | View/Open | |
12_chapter 4.pdf.pdf | 381.7 kB | Adobe PDF | View/Open | |
14_chapter 6.pdf.pdf | 325.03 kB | Adobe PDF | View/Open | |
15_summary and conclusion.pdf.pdf | 208.2 kB | Adobe PDF | View/Open | |
16_bio.pdf.pdf | 309.42 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 208.2 kB | Adobe PDF | View/Open |
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