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http://hdl.handle.net/10603/364076
Title: | Evaluation of hepatoprotective and antioxidant activity of Lagerstroemia speciosa extract against Isoniazid and Dapsone induced hepatotoxicity in Wistar rats |
Researcher: | Rohit Singh T |
Guide(s): | D Ezhilarasan |
Keywords: | Clinical Medicine Clinical Pre Clinical and Health Gastroenterology and Hepatology gas liver |
University: | Saveetha University |
Completed Date: | 2021 |
Abstract: | Excessive alcohol consumption, HBV and HCV infections, aflatoxin newlinecontaminated food, and non-alcoholic steatohepatitis are considered as important newlineetiological factors for the progression of CLD. According to WHO, India is newlineresponsible for 2.95% of total liver disease-related deaths, where HBV infection newlineand alcohol intake remained the most common cause of CLD, and primary runner newlinefor cirrhosis/HCC. Therefore, in this study, we investigated the cytotoxic, pro-apoptotic and cell cycle arresting potential of EBLE against newlinehepatocellular cancer cell line i.e. HepG2 cells newlineDILI is one of the most serious problem worldwide and it is a cause of newlineconcern. According to Devarbhavi et al. (2010), anti-tubercular drugs and dapsone newlinetogether responsible for 63% of DILI in the Indian patients. Hence, DILI poses a newlinechallenging clinical problem with respect to both diagnosis and management newline(Ezhilarasan, 2019). Despite significant advancement in diagnosis, hazard newlineidentification and risk mitigation, DILI continues to be a difficult task for drug newlinedevelopment and a major health concern worldwide (Mosedale and Watkins, newline2017). Therefore, in this study, we investigated the antioxidant and newlinehepatoprotective effect of EBLE against DDS alone, INH alone and DDS+INHinduced newlinehepatotoxicity in rats. newlineThe aim, objectives, hypothesis and ethical consideration are embodied in newlinethe forthcoming chapter of this thesis newline |
Pagination: | |
URI: | http://hdl.handle.net/10603/364076 |
Appears in Departments: | Department of Pharmacology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf.pdf | Attached File | 9.96 MB | Adobe PDF | View/Open |
02_certificate.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
03_declaration.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
04_acknowledgement.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
05_contents.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
06_list_of_tables.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
07_list_of_figures.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
08_abbreviations.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
09_chapter 1.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
10_chapter 2.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
11_chapter 3.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
12_chapter 4.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
13_chapter 5.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
14_chapter 6.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
15_chapter 7.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
16_chapter 8.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
17_summary and conclusion.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
18_bio.pdf.pdf | 9.96 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 9.96 MB | Adobe PDF | View/Open |
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