Preclinical Studies on Prevention of Metabolic Syndrome Linked Cancer by Targeting IGF 1R and FASN

Abstract

The clustering of various metabolic abnormalities within an individual was first deliberated by Dr. Reaven in his Banting lecture in 1988 (Reaven, 1988). While this phenotype has been given various names like Deadly Quartet, insulin resistance syndrome and syndrome X, it is now most commonly termed as the metabolic syndrome (MetS). newlineIn India, a multisite study by Deedwania et al. (2014) reports age adjusted prevalence (%, newline95% confidence intervals) of metabolic syndrome in men and women was 33.3% (31.7-34.9) newlineand 40.4% (38.6-42.2) respectively using harmonized criteria. The ICMR task force newlinecollaborative study reported the prevalence of MetS to be 30 per cent in urban areas of Delhi newlineand 11 per cent in rural Haryana using ATP-III criteria (CCDC India). There is also rising newlineapprehension on the term quotAsian Indian Phenotype,quot for Indians, which refers to newlinecharacteristics such as augmented insulin resistance, higher abdominal adiposity, dyslipidemia accompanied with low HDL cholesterol and higher LDL cholesterol. These metabolic abnormalities along with an increased ethnic susceptibility dispose Indians to high risk for diabetes and premature cardiovascular disease (Anjana et al. 2011). newlinePresent data from epidemiological, experimental, translational, and clinical studies brace the newlineevolving assumption that MetS may be a central etiological factor for the progression of newlinecertain types of cancer and also for overall cancer mortality (Zhou et al. 2007). newlineA recent systematic review and meta-analysis published by American Diabetes Association newline(ADA) reveals the association between MetS and risk of cancer at different sites. In this newlinestudy, Esposito et al. (2012) analyzed 116 datasets from 43 articles, including 38,940 cases of cancer. In the view of progressively increasing population of MetS affected people, targeting newlinemetabolic abnormalities may be an effective strategy in prevention of MetS associated newlinecancers. The proposed studies will provide understanding of mechanisms that link MetS and cancer.