Asymmetric Synthesis of 3 3 Disubstituted Oxindoles and Spirocyclic Oxindoles

Abstract

The chiral 3,3-disubstituted / spiro-oxindole framework is considered as a privileged heterocyclic motif. The enantiopure 3,3-disubstituted / spiro oxindole motif is present in many bioactive natural products and a series of pharmaceutically active compounds hence has gained significant attention by medicinal as well as synthetic chemists. These significant bioactivities and versatility newlineof 3,3-disubstituted / spiro-oxindole bearing natural products, drugs, and related analogs propelled us to develop newer methodologies for the asymmetric synthesis of 3,3-disubstituted oxindole and some important natural product and drug leads. newline