Nanoparticles A Novel Approach In Improvement Of Pharmacokinetic Profile Of Indian Origin Polyherbal Antidiabetic Formulations

Abstract

Diabetes mellitus is the most common endocrine disorder caused either by insufficient newlineinsulin secretion or insulin resistance. Existing oral anti-diabetic medications address newlinehypoglycemia but leads to many side effects. In addition to lack of efficacy and undesirable newlineadverse effects of synthetic drugs, herbal drugs are prescribed throughout the world in the newlinetreatment of diabetes. Recently, many studies focused on applying nanotechnology to plant newlineextracts for the enhancement of solubility, bioavailability and sustained delivery. Hence the newlinepresent study was designed to incorporate herbal treatment with nanotechnology approach. It newlinewas generally observed that instead of single herbal drug, combination of drugs reduces the dose newlineand increases the efficacy of total formulation. Hence in the present investigation single as well as newlinepolyherbal formulations were designed. newlineThe aim of present investigation is to formulate and evaluate polyherbal nanoparticle newlinedosage form and study its improvement in pharmacokinetic profile. Selection of herbal drugs like newlineGymnema sylvestre (leaves), Momordica charantia (fruits) and Synzigium cumini (seeds), its newlineextraction, study of phytochemical investigation, in vivo study of extracts, its conversion into newlinenanoparticles and its evaluation, stability study of nanoparticles and finally converted into tablet newlinedosage form and its evaluation are objectives of this study. newlineIn this study herbal extracts of all selected plants of different parts were prepared and newlineextracts were evaluated for their phytochemical and physical evaluation parameters. From In Vivo newlineacute toxicity study of extracts, it was observed that all selected herbal extracts does not show newlineany toxic effects and hypoglycemic study shows good antidiabetic activity, which supports newlinedetermination of dose of herbal drugs. newlineAfter study of extracts they are converted into silver nanoparticles by using green newlinesynthesis method which is simple and effective. From the evaluations of nanoparticles it were newlineobserved that batch NF1, NF3 and NF5 shows better acceptability and good