Effect of acetazolamide on fetal skeleton development in relation to central nervous system

Abstract

Teratogenic exposures play a vital role for clinicians, geneticists and newlinegenetic counselors. Recent progress in the field of genetics like cytogenetic newlinemicroarray analysis and exome sequencing helps to enhance details to newlinephysicians and family about etiology of birth defects. Recognition of nongenetic newlinefactors is also helpful for primary prevention. newlineIn recent years notable development has occurred in understanding newlineteratogenic exposure. Changes in living conditions, varied ailments,availability newlineof drugs is leading to congenital abnormalities at gestation theseanomalies newlineincrease morbidity and physical disability. Among many defects, only a few of newlinethem arise due to drug treatment. Acetazolamide a common diuretic drug newlinemostly used in medical conditions was found to cause specific limb newlineabnormalities. Hence there is a necessity to investigate the relationship newlinebetween skeletal deformities and central nervoussystem. newlineAim of thestudy newlineThe aim of the present study is to elucidate the involvement of central newlineneural structures on skeletal retardation induced by acetazolamide in Wistar newlinealbino rats newlineDrugs during prenatal newlineperiod may cause certain developmental abnormalities. So knowledge of newlineteratological effects of drugs plays vital role. Teratogen affects the embryo newlineduring the period of organogenesis, in human beings it extends from18th-21st newlinedays similarly it starts from 6th-10th day. Administration during this period may newlinecause congenital abnormalities. Acetazolamide is a carbonic anhydrase newlineinhibitor used to treat idiopathic intracranial hypertension, glaucoma, and newlineepilepsy. Its use is restricted for pregnant women because of reported newlineteratogenic risks involving unilateral forelimb abnormality in rodents. So the newlinepresent study observed its toxic effect on central nervous system and found newlinethat there is dose and time related difference in various morphometric newlineparameters among deformed and normal. newline