Evaluation of therapeutic potential of Ginkgo biloba extract on experimental model of fluorosis

Abstract

Toxic effects of fluoride can be reversed and ameliorated with newlinesupplementation of antioxidant rich nutrients. In Ayurveda and herbal newlinemedicine, nutrient based neuro protective plant extracts are used to treat newlineneurodegenerative disorders. However reports from such plant extracts are newlineminimal which reverse and lower the risks associated with fluoride toxicity. newlineHence the present study was carried out to ascertain if Ginkgo biloba extract newline(GBE) could exert neuroprotective potentials against fluoride induced toxicity newlinein rat model through hematological, biochemical, brain cholinergic activity and newlinegene expression, histological and cognitive assessment studies. newlineAim newlineThe aim of present thesis work was to evaluate the therapeutic newlinepotential of Ginkgo biloba extract (GBE) on experimental model of fluorosis in newlinerats.The newlinepresent study investigated the therapeutic as well as neuroprotective efficacy newlineof Ginkgo biloba extract (GBE) in experimental model of fluorosis. The newlineneuroprotective functions of Ginkgo biloba extract ameliorated the fluoride newlineinduced memory impairment by reversal of neuronal cell death in CA1 and newlineCA3 region of hippocampus caused by fluoride toxicity. Fluoride induced newlinebiochemical and serum enzyme parameter alterations were reversed by GBE. newlineBehavioral, serum enzymes, hematological, serum biochemical, newlinehistopathological and mGluR5 gene expression were tested to assess the newlineanti-oxidant efficacy, reversal of neuronal degeneration, memory and learning newlineimpairment and neuroprotection offered by GBE. Neuroprotective efficacy of newlineGinkgo biloba extract was confirmed by significant decrease in the fluoride newlineinduced elevation of acetyl cholinesterase (AChE) activity. Results of present newlinestudy concluded beneficial effects of Ginkgo biloba extract against fluoride newlinetoxicity in experimental model. newline