Evaluation of inflammatory markers steroidal hormones and gene polymorphisms in polycystic ovarian syndrome

Abstract

Polycystic ovarian syndrome is the most common and a complex newlineendocrinopathy especially in reproductive age women. About 5-10% of newlinepremenopausal women are affected by this syndrome. Chronic anovulation and newlinehyperandrogenism are the primary characteristic features. Several reports claim newlinedefects in insulin signaling, hypertension, dyslipidemia, disturbance in the newlineclotting mechanism including central obesity to be key features in PCOS. newlineSeveral epidemiological and clinical studies have confirmed the relationship newlinebetween obesity and reproductive problems in women. Chronic low grade newlineinflammation has been found to play a central role in the pathogenesis of newlineinsulin resistance and metabolic syndrome. Visceral adipose tissue secretes newlineadipokines and vasoactive substances that tend to stimulate inflammation newlinewhich interfere insulin and metabolic action in women with PCOS. Emerging newlinestudies describe that PCOS is a pro inflammatory state and chronic low grade newlineinflammation is responsible for the development of ovarian dysfunction and metabolic aberrations. Strong association has been observed between newlinehyperandrogenism and inflammation in PCOS due to diet induced inflammation. newlineHence, there is a need to evaluate the circulating concentrations of biochemical newlinemarkers of inflammation in a group of premenopausal women with PCOS. newlineBased on the overall results, the followings conclusions were derived: newlinea) Women characterized by a prevalence of metabolic abnormalities along newlinewith elevated BMI are playing a major role in the pathophysiology of newlinePCOS and may increase the risk of cardiovascular disease in these newlinewomen. newlineb) The increased levels of LH and decreased follicular production of newlineprogesterone and estradiol by preovulatory follicles may manifest newlineanovulation in PCOS. newlinec) High TNF-and#945; levels are responsible for increased fasting blood sugar, newlineHbA1C, DHEAS, SHBG while the hormones such as AMH, LH and newlineestradiol levels were found to decrease along with vitamin D ultimately newlinepredisposing a women develop PCOS.