Evaluation of Oxidative Stress and antioxidant Status in Patients Undergoing Treatment for Carcinoma Cervix

Abstract

Study entitled newlineEvaluation of Oxidative stress and Antioxidants in newlinepatients undergoing treatment for carcinoma cervix newlineAn Assessment of Serum Oxidative Stress and Antioxidant Parameters in Patients newlineUndergoing Treatment for Carcinoma Cervix newlineBackground/Objectives: Oxidative stress and antioxidants were involved in all newlineaspects of cervical Cancer, from initiation, progression, treatment, and recovery. The newlinepresent study was conducted to evaluate serum oxidative stress and antioxidants in newlinecervical cancer patients before therapy, during concurrent chemoradiotherapy, and at newlinesix months of follow up. The results were compared with controls, and their association newlinewith treatment outcome were investigated. newlineDesign and methods: Serum levels of oxidative stress parameters, 8-hydroxy-2- newlinedeoxyguanosine (8-OH-dG), Protein Carbonyl (PC), and Malondialdehyde (MDA) newlinealong with Total Antioxidant Status (TAS), Superoxide Dismutase (SOD), Catalase newline(CAT) and Glutathione Peroxidase (GPx) were measured in ninety-seven patients and newlinethirty subjects as control of same age, sex, and socio-economic status newlineResults: Significant rises in oxidative damage markers were observed in cervical newlinecarcinoma patients compared with the healthy controls; simultaneously, there was a newlinesignificant decrease in Antioxidant parameters also this pattern continuous further newlineduring the time of treatment. At the time of six months follow up, it is observed that the newlineoxidative stress markers and antioxidant parameters were normalized on complete newlineresponders. While in non responders the normalization of these parameters were not newlineobserved newline