Design Synthesis and Biological Evaluation of New Noscapinoids as Potential Anti Cancer Agents

Abstract

ABSTRACT newlineThe thesis entitled Design, synthesis and biological evaluation of new noscapinoids as newlinepotential anticancer agents has been divided into six chapters. newlineChapter I : General introduction to cancer, tubulin polymerase inhibitors and newlinenatural and#945;-noscapine. newlineChapter II : Copper catalyzed Glaser-Hey type cross coupling of 9-ethynyl newlinenoscapine leading to unsymmetrical 1,3-diynyl noscapinoids. newlineChapter III : Imidazo[2,1-b]thiazole coupled naturaland#945;-noscapine derivatives as newlineanticancer agents. newlineChapter IV : This chapter is subdivided into two sections A and B. newlineSection A : Anticancer potential of N-sulfonyl noscapinoids: Synthesis and newlineevaluation. newlineSection B : Design, synthesis and biological evaluation of N-imidazopyridine newlineand#945;-noscapine analogues as antiproliferative agents. newlineChapter V : This chapter is subdivided into two sections A and B. newlineSection A : Synthesis and biological evaluation of novel and#945;-noscapine urea newlinecongeners. newlineSection B : Synthesis and biological evaluation of novel N-alkyl amine newlineanalogues of and#945;-noscapine as anticancer agents. newlineChapter VI : Synthesis of dissected analogues of natural and#945;-noscapine.