Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/351737
Title: | Evaluation of in VITRO and in VIVO Anticancer Activity of Wedelia Chinesis and Wedelia Calendulacea |
Researcher: | Nithin Manohar R |
Guide(s): | Padmaja V |
Keywords: | Clinical Pre Clinical and Health Pharmacology and Pharmacy Pharmacology and Toxicology |
University: | Meenakshi Academy of Higher Education and Research |
Completed Date: | 2021 |
Abstract: | The present study confirmed that the ethanolic extract of Wedelia calendulacea and Wedelia chinesis exhibited antitumor and antioxidant activities against DAL and EAC in Swiss albino mice. When compared to the lower dose of the ethanolic extract, higher doses showed highly significant effects. The antitumor effects of ethanolic extract of Wedelia calendulacea and Wedelia chinesis are due to existence of phytochemical constituents with well known activity of free radical quenching activity. These externally administered antioxidants support the internal antioxidant system which fight against generated reactive oxygen species in diseased condition and maintain the balance between oxidants and antioxidant enzyme system in body. These antioxidant enzymes, attain huge importance by high merit of their significant role in disease prevention. The possible mechanism of antitumor effect may be due to stimulation of apoptotic pathway mediated through caspase-3 and hence associated with antioxidant effect. For discovery of a potent anticancer drug with high therapeutic index (TI) it is required to assess the antioxidant status which helps to improve the efficacy and clinical outcome of treatment. |
Pagination: | xx167 |
URI: | http://hdl.handle.net/10603/351737 |
Appears in Departments: | Department of Medicine |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 117.9 kB | Adobe PDF | View/Open |
02_certificate.pdf | 195.64 kB | Adobe PDF | View/Open | |
03_declaration.pdf | 293.04 kB | Adobe PDF | View/Open | |
04_chapter 1.pdf | 110.32 kB | Adobe PDF | View/Open | |
05_chapter 2.pdf | 111.43 kB | Adobe PDF | View/Open | |
06_chapter 3.pdf | 78.57 kB | Adobe PDF | View/Open | |
07_chapter 4.pdf | 734.95 kB | Adobe PDF | View/Open | |
08_chapter 5.pdf | 9.21 MB | Adobe PDF | View/Open | |
09_chapter 6.pdf | 209.44 kB | Adobe PDF | View/Open | |
10_chapter 7.pdf | 39.04 kB | Adobe PDF | View/Open | |
11_bibliography.pdf | 157.8 kB | Adobe PDF | View/Open | |
12_annexures.pdf | 1.76 MB | Adobe PDF | View/Open | |
13_content.pdf | 79.29 kB | Adobe PDF | View/Open | |
14_list of tables and figures.pdf | 2 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 153.04 kB | Adobe PDF | View/Open |
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