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http://hdl.handle.net/10603/351011
Title: | Friedel crafts reactions with alkenes Stereoselective synthesis of 1 1diarylalkanes |
Researcher: | Bhattacharya, Aditya |
Guide(s): | Maji, Biswajit |
Keywords: | 1,1-Diaryl alkane and#945;-Halo-and#946;,and#946;-Diaryl Carbonyl Compound Chemistry Chemistry Physical Chroman Friedel-Crafts alkylation Physical Sciences Tetrahydroquinoline |
University: | Indira Gandhi National Tribal University, Amarkantak |
Completed Date: | 2021 |
Abstract: | Friedel-Crafts alkylation reaction, most probably, is the oldest organic reaction where first time a newlineLewis acid is utilized. Owing to high synthetic value of Friedel-Crafts alkylated products, the newlinedevelopment of newer and milder catalytic methods for Friedel-Crafts-type alkylations has been newlineprogressed rapidly over last few decades (Scheme 1). The features of these catalytic processes newlineare outstanding levels of chemo-, regio- or even stereo-selectivities. An asymmetric strategy of newlinethis racemic version gives enantioenriched arene-alkylated products. More recently, these newlinestrategies are frequently used to construct numerous natural products with complex architecture newlineand bioactive drug-like molecules. A brief overview of the Friedel-Crafts alkylations will be newlinepresented in Chapter I. newlineAn important strategy to prepare 1,1-diarylalkanes is Friedel-Crafts-type hydroarylation newlinereaction with olefins. The outmost advantage of these hydroarylation methods is hundred percent newlineatom-efficient product formations. In this Chapter II, we have developed a mild and newlineefficient iron triflate catalyzed Friedel-Crafts-type alkylation between and#945;,and#946;-unsaturated newlinecarbonyl compounds and electron rich benzenoid arene components (Scheme 2). This newlinereaction provides exclusively and#946;, and#946;-diaryl carbonyl compounds in good to excellent yields. newlineA series of control reactions including isotope labeling experiments helps to deduce a newlineplausible reaction mechanism. newlineAr1H Ar2 R newlineAr2 R newlineAr1 newlineR = COAr, CO2Me newlineFe(OTf)3 (10 mol%) newlineDCE, 85 C newline65-93% newline17 examples newline° newlineScheme 2 Iron-triflate-catalyzed Intermolecular Friedel-Crafts-type alkylations. |
Pagination: | |
URI: | http://hdl.handle.net/10603/351011 |
Appears in Departments: | Department of Chemistry |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 441.59 kB | Adobe PDF | View/Open |
02_daclaration.pdf | 781.7 kB | Adobe PDF | View/Open | |
03_certificte.pdf | 840.33 kB | Adobe PDF | View/Open | |
04_acknowledgement.pdf | 305.91 kB | Adobe PDF | View/Open | |
05_abstracts.pdf | 116.94 kB | Adobe PDF | View/Open | |
06_list of abbreviations.pdf | 424.24 kB | Adobe PDF | View/Open | |
07_preface.pdf | 422.61 kB | Adobe PDF | View/Open | |
08_tables of contents.pdf | 594.54 kB | Adobe PDF | View/Open | |
09_list of appendices.pdf | 2.36 MB | Adobe PDF | View/Open | |
10_chapter 01.pdf | 943.63 kB | Adobe PDF | View/Open | |
11_chapter 02.pdf | 1.5 MB | Adobe PDF | View/Open | |
12_chapter 03.pdf | 1.86 MB | Adobe PDF | View/Open | |
13_chapter 04.pdf | 2.82 MB | Adobe PDF | View/Open | |
14_chapter 05..pdf | 1.58 MB | Adobe PDF | View/Open | |
15_profile.pdf | 608.05 kB | Adobe PDF | View/Open | |
16_research paper.pdf | 894.16 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 2.02 MB | Adobe PDF | View/Open |
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