Studies on Novel Organotin IV Derivatives of Hydrazino Schiff bases and or quinolones containing hetero donor ligands

Abstract

The chemistry of organotin(IV) compounds has emerged as one of the strongest areas in the interdisciplinary organometallic field owing to their wide spectrum of industrial, synthetic and biological applications [Davies et al. (2008)]. Organotin(IV) compounds have been used as stabilizers for poly(vinyl)chloride, curing agents for the room temperature vulcanization of silicones, industrial biocides in material protection as an antifouling agent, surface disinfectants, versatile and efficient synthetic reagents for a wide range of organic transformations, and catalysts for the production of polyurethanes [Davies (2004); Davies et al. (2008); Nath (2008)]. Further, the structural diversity which can be attained by simple structural modification and also in the form of design of novel cluster types has created a prominent position for organotin(IV) compounds in the field of organometallic chemistry [Chandrasekhar et al. (2002)]. However, their chemistry has experienced a quantum growth in the last few decades because of their emergence as potential biologically active metallopharmaceuticals exhibiting broad spectrum of biological activity more significantly anti-tumour/anticancer, antimicrobial, anti-inflammatory and antiviral activities [Nath (2008); Arjmand et al. (2014); Carraher and Roner (2014); Shah et al. (2015)]. Their significance from chemotherapeutic point of view has been enhanced further, owing to their interaction with diverse range of active drugs having hetero {N/O/S} donor atoms exhibiting good in vitro antiproliferative, antituberculosis and antiviral activities [Kovala-Demertzi (2006); Koval-Demertzi et al. (2009); El-Gamel (2009); Dokorou et al. (2011); Kumari and Nath (2017)]. newline