Characterization of Neem Gum Azadirachta indica and Kheri Gum Acacia chundra as Pharmaceutical Excipient

Abstract

Present research deals with the extraction and characterization of Neem Azadirachita indica family Meliaceae NGP and Kheri Acacia chundra Family Mimosaceae KGP gum polysaccharides. In present research acrylamide grafting and carboxymethylation of Neem and Kheri gum polysaccharides were carried out under microwave irradiation; furthermore modified polymers were utilized as drug delivery carriers. newline newlineFindings showed that NGP and KGP can be utilized as a suspending agent Acrylamide grafted copolymers were not suitable to prepare suspension in the same concentration range. Carboxymethylated copolymers had not shown the formation of a suspension due to high solubility and very low viscosity of copolymers. newline newlineIt was found that NGP and KGP can be utilized as an emulsifying agent in the concentration range of 0.5 to 1.5 percent weight by volume. newline newlineNGP and KGP were utilized and showed good binding properties in the tablet dosage form. Both the polymers were also showed good disintegrating properties in specific concentration range. newline newlineNanoparticles were prepared using factorial design. Results predicts formation of nanoparticles. newline newlineVarious concentrations of polymer were used to prepare in situ gastro retentive floatable gel-forming systems and results easilty predicts formation of the same. newline newlineNGP and KGP and chitosan were used to fabricate polyelectrolyte stabilized nanoparticles. Results easily predict that etoricoxib nanoparticles can be used in place of pure etoricoxib for the management of inflammation and pain associated with breast cancer. newline newlineDifferent concentrations of polysaccharides and chitosan were utilized to prepare transdermal film using the solvent casting method. All the fabricated films were found efficient to deliver drug for extended period. newline newline