Forced Degradation Studies on Saxagliptin with Metformin Vildagliptin with Metformin Candesartan Cilexetil with Hydrochlorothiazide Irbesartan with Hydrochlorothiazide Regorafenib Sorafenib Gefitinib Drugs in Bulk and in Pharmaceutical Formulation for the Development of a Validated Specific Stability Indicating Spectrofluorimetric RP HPLC and HPTLC Methods

Abstract

Few RP-HPLC, HPTLC and Spectrofluorimetric methods were reviewed for the estimation of anti-cancer, anti-diabetic and anti-hypertensive drugs in single as well as in combined dosage forms. For this study three anti-cancer drugs in single, two anti-diabetic drugs in combined dosage forms and two anti-hypertensive drugs in combined dosage forms were selected and they were subjected to analytical estimation including stress degradation study wherever they were applicable.A stability indicating RP-HLC methods were developed for the estimation of anticancer newlinedrugs Gefitinib, Sorafenib and Regorafenib in bulk and pharmaceutical dosage forms. To check the stability indicating nature of developed RP-HPLC methods, forced degradation of drugs were carried out under acidic, basic, oxidative, thermal, photolytic and hydrolytic conditions. A stability indicating RP-HLC methods were developed for the estimation of antidiabetic drugs Saxagliptin with Metformin and Vildagliptin with Metformin in bulk and pharmaceutical dosage forms. To check the stability indicating nature of developed RPHPLC methods, forced degradation of drugs were carried out under acidic, basic, oxidative, thermal, photolytic and hydrolytic conditions. A stability indicating HPTLC methods were developed for the estimation of antihypertensive drugs Irbesartan with Hydrochlorothiazide and Candesartan cilexetil with Hydrochlorothiazide in bulk and pharmaceutical dosage forms. To check the stability indicating nature of developed HPTLC methods, forced degradation of drugs were carried out under acidic, basic, oxidative, thermal, photolytic and hydrolytic conditions. A novel and precise Spectrofluorimetric method was developed for the estimation of anti-cancer drugs Gefitinib in bulk and pharmaceutical dosage form. Newly developed stability indicating RP-HPLC and HPTLC methods were successfully applied to determine the drugs content from the pharmaceutical dosage forms in presence of their degradation products. newline newline