Formulation and Evaluation of Proniosomes for Anticancer Drugs

Abstract

Currently proniosomes have been studied by researcher as a choice of oral drug delivery system for anticancer drugs to provide a better oral bioavailability considering, high penetration property of the niosome encapsulated agents through biological membrane and the stability of them. newlineCancer is a leading cause of death worldwide. The four most common cancers occurring worldwide are lung, female breast, bowel and prostate cancer. Breast cancer is the most frequently diagnosed cancer and the primary cause of cancer-related death in women worldwide. Aromatase inhibitors and selective oestrogen receptor modulator are used for the treatment of breast cancer in postmenopausal women. The most important goal of cancer chemotherapy is to minimize the exposure of normal tissues to drugs while maintaining their therapeutic concentration in tumors. newlineProniosomes proved to be the potential carriers for efficient oral delivery of lipophilic or amphiphilic drugs. Henceforth an attempt was made to improve the oral delivery of letrozole and raloxifene by loading into maltodextrin based proniosome powders separately. newlineLetrozole loaded maltodextrin based proniosomes and raloxifene loaded maltodextrin based proniosomes were prepared by slurry method with different ratio of span 20, span 60 and cholesterol and evaluated for flow properties and the results indicated acceptable flow properties. newlineIn conclusion, we can state that, besides providing the controlled systemic delivery of letrozole and raloxifene, an attempt was made to prepare proniosomal drug delivery system and evaluate its performance. Proniosome provides an effective means of delivering the drug through the oral route. The stable proniosome formulation was prepared and it is highly successful in enhancing oral bioavailability of the drug. Thus a dry free flowing product like proniosomes will be a promising industrial product. newline