Pharmacological Screening of Hepato and Nephro Protective Activity of the Leaves of Orthosiphon Stamineus and Coccinia Grandis Leaves in Male Wistar Rat

Abstract

The thesis entitled Pharmacological screening of Hepato and Nephroprotective activity of Orthosiphon stamineus and Coccinia grandis leaves in male wistar rats deals with phytochemical and pharmacological investigation of traditionally used medicinal plants. A perusal of the literature revealed that only fragmentary information was available on these plant species regarding pharmacological activity by any other researchers. Plants are becoming potential source for phytoconstituents with varied pharmacological activities. Identification of such plants of potential use in medicine is of significance. Cells in humans and other organisms are constantly exposed to a variety of oxidizing agents, some of which are necessary for life. In the status of normal metabolism, levels of newlineoxidants and antioxidants in humans are maintained in balance, which is important for sustaining optimal physiological conditions. Overproduction of oxidants in certain conditions can cause an imbalance, leading to oxidative damage to large biomolecules such as lipids, DNA, and proteins. Many synthetic drugs protect against oxidative damage but they have adverse side effects. Recently, there has been a considerable interest in finding natural antioxidants from plant materials to replace synthetic ones. Natural antioxidant substances are presumed to be safe since they occur in plant foods, and are seen as more desirable than their synthetic counterparts. Data from both scientific reports and laboratory studies show that plants contain a large variety of substances called plant chemicals or newline phytochemicals that possess antioxidant activity. newlineCONCLUSION: In my research I found the effective herb-herb combination therapy for both acute and chronic conditions of kidney and liver failure. Orthosiphon stamineus and Coccinia grandis herb-herb combination therapy (1:1) exhibited stongest nephroprotective and hepatoprotective activity especially for treating the following acute and chronic conditions such as Kidney diseases. newline