Phytomedicinal and Pharmacological studies of Selective Plants of Kolli Hills and Development of Standardisation Methods for its Formulation

Abstract

The thesis entitled Phytomedicinal and Pharmacological Studies of Selective Plants of Kolli hills and Development of Standardization Methods for its Formulation is an attempt to investigate and carry out a scientific study on medicinal plants of Kolli hills. From the initial study, the plants of Kolli hills such as Justicia gendarussa Burm, Rungia pectinata Nees, Strobilanthes ciliatus Nees and Rhinacanthus nasutus Linn belonging to the family Acanthaceae were investigated for its phytochemical, ethnomedicinal and pharmacological properties. Based on the comparative analysis Strobilanthes ciliatus Nees was chosen for further studies from the selected plants. This thesis work embodies pharmacognostic, phytochemical and pharmacological study of whole plant of Strobilanthes ciliatus Nees. In addition formulation development, evaluation of formulation parameters and development of standardization method using an isolated phytochemical marker was studied. A detailed pharmacognostical evaluation of the leaves, stem and root was carried out for Strobilanthes ciliatus Nees. Morphoanatomy has been studied to aid pharmacognostic and taxonomic species identification using physiochemical determinations and standard phytochemical procedures. The physiochemical, morphological and histological parameters presented may be proposed as parameters to establish the authenticity of Strobilanthes ciliatus Nees. The studies indicate the therapeutic potential of whole plant of Strobilanthes cliatus Nees and justify the traditional uses of this plant. The plant may prove to be promising in the management and alleviation of painful inflammatory conditions, hyperglycemia, hepatic diseases, cough, cytotoxic and aging related disorders. All the studies performed provides a strong evidence for the use of the Strobilanthes ciliatus Nees as a potent medicinal plant and novel solid dosage forms containing Strobilanthes ciliatus Nees extract that can be used as an alternative remedy for management and treatment of various Non-communicable diseases.