Designing fabrication and evaluation of controlled drug delivery systems of some potential anti diabetic drugs using synthetic and natural polymers

Abstract

The main objects of the present study was to develop a formulation with increase in therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing controlled release matrix tablets and matrix type transdermal patches of Glipizide, Glimepiride with synthetic and natural polymers. This work aims at investigating and formulating controlled release matrix tablets and matrix type transdermal patches of anti-diabetic drugs(Glipizide and Glimepiride) using easily available and economical polymers. The matrix tablets were prepared with various ratios of synthetic (Povidone) and natural (Aloe barbadensis miller leaf mucilage and Guar gum) polymers. The matrix transdermal patches were prepared with various ratios of synthetic (Povidone) and natural (fruit mucilage of Ficus bengalensis, Ficus carica and Ficus glomerata) polymers. Since scare attempts has been made on Aloe barbadensis miller leaf mucilage as controlled releasing polymer for developing matrix tablets. So, physicochemical characterization of Aloe barbadensis miller has made for reproducibility of results. Since no attempts has been made on Ficus bengalensis, Ficus carica and Ficus glomerata fruit mucilages as controlled releasing polymer for developing transdermal patches. So, physicochemical characterization of Ficus bengalensis, Ficus carica and Ficus glomerata has made for reproducibility of results. These natural polymers (Aloe barbadensis miller leaf mucilage, Ficus bengalensis, Ficus carica and Ficus glomerata fruit mucilage) in addition to controlled releasing properties have proven anti diabetic properties. Hence the author has selected these in his research.