The role of citric acid and tyrosine on nicotine toxicity in Wistar rats

Abstract

The present study aims to evaluate the effect of citric acid and tyrosine on nicotine receptor density, nicotine levels, dopamine levels, brain tissue damage and other organs damage induced by nicotine in rats. Objectives of the study newlineI. To evaluate the effect of citric acid and tyrosine on nicotinic receptor newlinedensity, dopamine levels and nicotine levels newlineII. To evaluate the effect of citric acid and tyrosine on histomorphometry and histology of brain newlineIII. To evaluate the effect of citric acid and tyrosine on histology of skin, lungs, liver, and pancreas newlineThe study and concludes that the CA and newlineTY can reduce nicotine levels and maintain dopamine levels. Hence during newlineabstinence of nicotine, the dopamine levels are maintained, which will sustain newlinethe pleasurable feeling. This can control the withdrawal symptoms, stop newlinecraving for nicotine, and finally lead to the cessation of smoking or taking newlinenicotine therapy. Citric acid and tyrosine decrease nicotine levels. Nicotinic newlinereceptor density increases when a person or an animal is exposed to nicotine. newlineIt plays a significant role in the addiction and withdrawal symptoms. It takes almost 6 to 8 weeks of abstinence to bring back the NRD to normal. If a newlineperson stops smoking for a few days, the NRD encourages the person for newlineanother cigarette. Hence without decreasing the NRD, it is not possible to newlinemake the person quit smoking. On the other hand, the increase in NRD will newlineeventually addict the person. Nicotine not only causes dangerous reversible newlineand irreversible health hazards, but it also causes various tissue damage. newlineCitric acid and tyrosine treated groups have reduced brain tissue damage. newlineHence citric acid and tyrosine can protect the nicotine-induced tissue damage. newlineSimilar conclusions were made through histopathology of lungs, skin, liver newlineand pancreas that the use of citric acid and tyrosine can reduce the tissue newlinedamage caused by chronic nicotine us. newline