Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/3456
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dc.coverage.spatialChemistryen_US
dc.date.accessioned2012-04-19T06:27:57Z-
dc.date.available2012-04-19T06:27:57Z-
dc.date.issued2012-04-19-
dc.identifier.urihttp://hdl.handle.net/10603/3456-
dc.description.abstractAn accurate and precise gradient stability indicating reverse phase high performance liquid chromatographic method is developed for simultaneous determination of sibutramine hydrochloride and Orlistat in the newly developed capsule formulation. The chromatography equipped with Zorbax SB Phenyl (250×4.6mm) 5µ column using a mobile phase of buffer (Dissolved 7.0 g of sodium perchlorate in 1000ml water, pH adjusted to 2.1 (+ 0.05) with ortho phosphoric acid, filtered through 0.45 µ filter.) and acetonitrile, the gradient program configured with a flow rate of 2.0 ml/min, ultraviolet detector at 210nm. The retention times of sibutramine hydrochloride and Orlistat were 8 and 31 min respectively. The method linearity was studied over the range of 50 to 150 ppm with r2 of 0.9999 for sibutramine hydrochloride and 600 to 1800 ppm with r2 of 0.9999 for Orlistat. Mean recovery for sibutramine hydrochloride and Orlistat were 100.09 and 100.02 respectively A simple fast, accurate, precise, and cost effective isocratic stability indicating reverse phase high performance liquid chromatographic method is developed for simultaneous determination of Halobetasol propionate and fusidic acid as well as its impurities in the newly developed cream formulation. The chromatography equipped with Zorbax SB phenyl (250X4.6mm) column using a mobile phase of buffer (0.1% triethylamine buffer pH adjusted to 2.0 with Orthophosphoric acid) acetonitrile, methanol in the ratio of 40:35:25 v/v with a flow rate of 1.5 ml/min, with ultraviolet detector configured at 240nm. Identified all impurities and Characterization of Sibutramine Hydrochloride Impurities.en_US
dc.format.extent268p.en_US
dc.languageEnglishen_US
dc.relationNo. of References 218en_US
dc.rightsuniversityen_US
dc.titleNew analytical methods development and identification and characterization of impurities in pharmaceuticalsen_US
dc.creator.researcherAnkam, Rajeshen_US
dc.subject.keywordChemistryen_US
dc.subject.keywordOrlistaten_US
dc.subject.keywordPharmaceuticalsen_US
dc.description.noteReferences p. 250-267, Research publications p. 267-268en_US
dc.contributor.guideMukkanti, Ken_US
dc.contributor.guideDurga Prasad, Aen_US
dc.publisher.placeKukatpallyen_US
dc.publisher.universityJawaharlal Nehru Technological Universityen_US
dc.publisher.institutionFaculty of Chemistryen_US
dc.date.registeredn.d.en_US
dc.date.completedMay, 2010en_US
dc.date.awarded2010en_US
dc.format.accompanyingmaterialNoneen_US
dc.type.degreePh.D.en_US
dc.source.inflibnetINFLIBNETen_US
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File308.56 kBAdobe PDFView/Open
02_certificates.pdf261.89 kBAdobe PDFView/Open
03_acknowledgements.pdf245.3 kBAdobe PDFView/Open
04_abstract.pdf172.95 kBAdobe PDFView/Open
05_table of contents.pdf272.32 kBAdobe PDFView/Open
06_list of tables & figures.pdf290.66 kBAdobe PDFView/Open
07_abbreviations.pdf225.25 kBAdobe PDFView/Open
08_chapter 1.pdf334.5 kBAdobe PDFView/Open
09_chapter 2.pdf3.34 MBAdobe PDFView/Open
10_chapter 3.pdf532.95 kBAdobe PDFView/Open
11_chapter 4.pdf673.29 kBAdobe PDFView/Open
12_chapter 5.pdf489.72 kBAdobe PDFView/Open
13_chapter 6.pdf682.86 kBAdobe PDFView/Open
14_chapter 7.pdf427.89 kBAdobe PDFView/Open
15_references.pdf494.97 kBAdobe PDFView/Open
16_research publications.pdf236.75 kBAdobe PDFView/Open


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