Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/344645
Title: | Synthesis Characterization and Pharmacological Evaluation of Submitted Flavones |
Researcher: | Helen William |
Guide(s): | Anbarasu, K |
Keywords: | Engineering Engineering and Technology Engineering Biomedical |
University: | Periyar Maniammai University |
Completed Date: | 2019 |
Abstract: | Flavonoids are a large group of plant secondary metabolites having a wide newlinevariety of pharmacological activities such as antioxidant, antimicrobial, antiinflammatory, analgesic, antiviral, hepatotoxic, anticancer etc. The surfeit of activities newlinemakes the flavonoids a very interesting class of biologically active compounds. These newlinenaturally occurring flavone moieties with a wide array of pharmacological activities newlinecan function as lead for further synthesis of semi-synthetic and synthetic derivatives. newlineNatural plant flavonoids are widely available, however the process of newlineidentification and separation is very tedious, time consuming and expensive. Hence to newlineovercome this challenge, alternatively synthesis of flavonoids are considered more newlineideal as the process is simple and derivatization of the compounds is easier as newlinecompared to natural flavonoids. Hence the present study was designed to prepare newlinesynthetic flavones and evaluate them for various pharmacological activities. newlineThe structure of the flavonoids plays a major role in determining their newlinepharmacological activity. One of the most important feature of flavonoids is the newlinepresence of 2,3- unsaturation in the C ring and the number and position of hydroxyl newlinegroups in the A and B rings which have a prominent effect on the antioxidant and newlineanticancer activity of these compounds. The presence of a catechol group on ring B newline(3 , 4 -OH) significantly enhanced antioxidant activity. It is also seen in certain newlinestudies that the methoxylated flavones gave better antiproliferative effect than the newlinehydroxylated flavones. newlineTaking into consideration the above structural activity relationship findings, newlinethe study was designed to synthesize substituted derivatives and to study various newlinepharmacological effects such as antioxidant, antimicrobial, anti-inflammatory and newlineantiproliferative effects. |
Pagination: | |
URI: | http://hdl.handle.net/10603/344645 |
Appears in Departments: | Department of Biotechnology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
10 chapter 1.pdf | Attached File | 406.16 kB | Adobe PDF | View/Open |
11 chapter 2.pdf | 300.11 kB | Adobe PDF | View/Open | |
12 chapter 3.pdf | 99.43 kB | Adobe PDF | View/Open | |
13 chapter 4.pdf | 322.05 kB | Adobe PDF | View/Open | |
14 chapter 5.pdf | 5.17 MB | Adobe PDF | View/Open | |
15 chapter 6.pdf | 153.31 kB | Adobe PDF | View/Open | |
16 chapter 7.pdf | 130.63 kB | Adobe PDF | View/Open | |
17 references.pdf | 273.91 kB | Adobe PDF | View/Open | |
18 list of publications.pdf | 16.91 kB | Adobe PDF | View/Open | |
1 first page.pdf | 49.03 kB | Adobe PDF | View/Open | |
21 appendix 1.pdf | 555.35 kB | Adobe PDF | View/Open | |
22 curriculum vitae.pdf | 92.71 kB | Adobe PDF | View/Open | |
2 certificate.pdf | 98.8 kB | Adobe PDF | View/Open | |
3 declaration.pdf | 42.19 kB | Adobe PDF | View/Open | |
4 acknowledgement.pdf | 99.65 kB | Adobe PDF | View/Open | |
5 contents.pdf | 63.09 kB | Adobe PDF | View/Open | |
6 abstract.pdf | 104.4 kB | Adobe PDF | View/Open | |
7 list of tables.pdf | 63.41 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 130.63 kB | Adobe PDF | View/Open | |
8 list of figures.pdf | 95.42 kB | Adobe PDF | View/Open | |
9 list of abbreviations.pdf | 121.82 kB | Adobe PDF | View/Open |
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