Formulation and Development of Oral Sustained Release Systems for Selected Drug Candidates

Abstract

This thesis deals with the investigations carried out by the writer with the objective of developing oral sustained release formulations for widely used antiviral drug acyclovir and anti emetic drug prochlorperazine maleate for the evaluation of their sustained release potential with the commercially available immediate release tablets. The first chapter of the thesis deals with a brief introduction to the conventional drug therapy, concept of sustained release drug delivery system, its relevance with respect to oral drug delivery, the anatomy and physiological considerations of the GIT, oral controlled release drug delivery system, significance and reasons for developing oral controlled release drug delivery system (CRDDS), ideal drug candidates for CRDDS, types of sustained/controlled release products, monolithic matrix system as oral CRDDS, mechanism of drug release from HPMC matrix system and estimation of drugs in biological medium. Literature survey on the investigations that have been carried out so far on the development of sustained release drug delivery systems and current developments for the selected drug candidates is being mentioned. The aim and objectives along with the place of work is presented in the second chapter of the thesis. In particular, it explains the need for designing a suitable drug delivery system for the drug candidates selected in the present investigation. The third chapter of the thesis explains in detail the experimental procedures that were adopted, namely preformulation studies, formulation and evaluation of sustained release sustained release tablets, stability studies of the developed formulations, bioanalytical method development with its validation and bioavailability studies. The fourth chapter describes in detail the experimental results obtained in the present study along with detailed discussion of the results supported by photographic plates, tables and figures. newline