1. Shodhganga@INFLIBNET
  2. The Tamil Nadu Dr. M.G.R. Medical University
  3. Department of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/344620
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dc.date.accessioned2021-10-18T04:20:50Z-
dc.date.available2021-10-18T04:20:50Z-
dc.identifier.urihttp://hdl.handle.net/10603/344620-
dc.description.abstractThe present work is based on the transdermal drug delivery of herbal drugs. newline Two plants Ficus racemosa and Calotropis gigantea were selected for wound healing activity. newline From each plant, 3 fractions, totally 6 fractions were isolated successfully. From the pharmacological studies, it was proved that both plants possess wound healing activity but fractions FRfr3 and CGfr3 of Ficus racemosa and Calotropis gigantea respectively were found to possess prominent and predominant wound healing activities. newline Hence, transdermal drug delivery systems for fractions of Ficus racemosa (FRfr3), Calotropis gigantea (CGfr3) and its combination (FRfr3 +CGfr3) were formulated and evaluated. The formulations successfully released active part in a controlled fashion up to 24h. newline The bioavailability of the herbal drugs was enhanced by transdermal drug delivery approach. The three formulations exhibited the ideal characters for transdermal drug delivery systems including in vitro and in vivo studies. newline In vitro cytotoxicity studies confirmed the absence of cytotoxicity for the transdermal patches. newline The transdermal patches CGFR-3, FRFR-3 and FRFR-3+CGFR-3 showed notable wound healing activity in both excision and incision wound models when applied topically. Among three test patches FRFR-3+CGFR-3 exhibited effective wound healing activity, followed by FRFR-3 and CGFR-3 in both Excision and Incision wound models. This maximal effect of FRFR-3+CGFR-3 might due to the synergistic action of CGFR-3 and FRFR-3. newline Stability studies conducted for 90 days at 40ºC ± 2ºC / 75% ± 5% RH confirmed that all the transdermal patches were stable. newline Hence it can be concluded that the newly developed formulation-transdermal drug delivery systems with herbal drugs (Ficus racemosa and Calotropis gigantea) is considered to be potential and effective in the management of wound healing and its related disease conditions. newline
dc.format.extent179
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleDesign Development of a Novel Transdermal Drug Delivery System as Wound Dressing
dc.title.alternative
dc.creator.researcherManivannan S
dc.subject.keywordDesign, Development
dc.subject.keywordNovel Transdermal Drug Delivery System
dc.subject.keywordWound Dressing
dc.description.note
dc.contributor.guideRavichandiran V
dc.publisher.placeChennai
dc.publisher.universityThe Tamil Nadu Dr. M.G.R. Medical University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered
dc.date.completed2012
dc.date.awarded
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File155.9 kBAdobe PDFView/Open
03_preliminary pages.pdf142.12 kBAdobe PDFView/Open
04_chapter 1.pdf375.24 kBAdobe PDFView/Open
05_chapter 2.pdf22.19 kBAdobe PDFView/Open
06_chapter 3.pdf516.41 kBAdobe PDFView/Open
07_chapter 4.pdf118.24 kBAdobe PDFView/Open
08_chapter 5.pdf114.67 kBAdobe PDFView/Open
09_chapter 6.pdf1.13 MBAdobe PDFView/Open
10_chapter 7.pdf1.49 MBAdobe PDFView/Open
11_chapter 8.pdf348.13 kBAdobe PDFView/Open
12_chapter 9.pdf602.77 kBAdobe PDFView/Open
13_chapter 10.pdf713.15 kBAdobe PDFView/Open
14_references.pdf222.19 kBAdobe PDFView/Open
80_recommendation.pdf271.44 kBAdobe PDFView/Open
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